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生物統計の実践

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名大生物統計の教室員は、多くの医学研究に共同研究者等の立場で参画し、実際に研究デザインとデータ解析を担当することで医学研究を支援しています。以下は、教室員がこれまでに関与した医学研究の一部です。様々な疾患、様々なタイプの研究が含まれています。生物統計の実践を偏りなく積み重ねていけば、これに近い形になるでしょう。これからも以下のリストはますますバラエティーに富んでいくことでしょう。

生物統計の研究とはどんなものでしょうか？

  • Emoto R, Nishikimi M, Shoaib M, Hayashida K, Nishida K, Kikutani K, Ohshimo S, Matsui S, Shime N, Iwami T. Prediction of pre-hospital change of the cardiac rhythm from non-shockable to shockable in out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry. Journal of the American Heart Association 2022 (Accepted).
  • Yasuda Y, Nishikimi M, Matsui K, Numaguchi A, Nishida K, Emoto R, Matsui S, Matsuda N. The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry. Resuscitation 2021; 168: 103-109.
  • Hiraiwa H, Kasugai D, Ozaki M, Goto Y, Jingushi N, Higashi M, Nishida K, Kondo T, Furusawa K, Morimoto R, Okumura T, Matsuda N, Matsui S, Murohara T. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock. Sci Rep 2021; 11: 18823.
  • Yoshihara M, Emoto R, Kitami K, Iyoshi S, Uno K, Mogi K, Tano S, Yoshikawa N, Matsui S, Kajiyama H. A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer. Sci Rep 2021; 11: 15154.
  • Kasugai D, Ozaki M, Nishida K, Goto Y, Takahashi K, Matsui S, Matsuda N. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis. Sci Rep 2021; 11: 14033.
  • Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsui S, Teramukai S, Murotani K, Ajioka Y, Shimazaki H, Maeda A, Takuma K, Yoshida T, Kambara T, Matsuda K, Takagane A, Tomita N, Sugihara K; SACURA Study Group. Optimal criteria for G3 (poorly differentiated) stage II colon cancer: prospective validation in a randomized controlled study (SACURA Trial). Am J Surg Pathol. 2020; 44: 1685-1698.
  • Nishida Y, Hamada S, Urakawa H, Ikuta K, Sakai T, Koike H, Ito K, Emoto R, Ando Y, Matsui S. Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial. Cancer Sci. 2020; 111: 4187-4194.
  • Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, Vitaly K, Itahashi K, Maeda Y, Matsui S, Shibahara T, Yamashita Y, Irie T, Tsuge A, Fukuoka S, Kawazoe A, Udagawa H, Kirita K, Aokage K, Ishii G, Kuwata T, Nakama K, Kawazu M, Ueno T, Yamazaki N, Goto K, Tsuboi M, Mano H, Doi T, Shitara K, Nishikawa H. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies. Nat Immunol. 2020; 21: 1346-1358.
  • Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. Journal of Anesthesia 2020; 34: 72-78.
  • Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K; SACURA Study Group. Prospective multicenter study on the prognostic and predictive impact of tumor budding in stage II colon cancer: Results from the SACURA trial. Journal of Clinical Oncology 2019; 37: 1886-1894. 
  • Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation 2019; 140: 135-141.
  • Anzai T, Takahashi K, Watanabe M. Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database. Psychiatry and Clinical Neurosciences 2019; 73: 27-33.
  • Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M. [Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a. Neuron 2019; 101: 60-75.
  • Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S. Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice. Free Radic Res. 2018; 52: 1030-1039.
  • Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N. Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial. Critical Care Medicine 2018; 46: 1099-1105.
  • Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Ichikawa M, Ogasawara T, Shindoh J, Nomura F, Yagi T, Yamamoto M, Taniguchi H, Suzuki R, Saka H, Matsui S, Hasegawa Y. Implication of β-lactam plus macrolide combination therapy on mortality in patients with community-onset pneumonia at low risk for drug-resistant pathogens. Respirology 2018; 23: 526-534.
  • Matsuhisa T, Takahashi N, Aomatsu M, Takahashi K, Nishino J, Ban N, Mercer SW. How many patients are required to provide a high level of reliability in the Japanese version of the CARE Measure? A secondary analysis. BMC Family Practice 2018; 19: 138.
  • Tominaga Y, Aomori T, Hayakawa T, Kijima N, Morisky DE, Takahashi K, Mochizuki M. Possible associations of personality traits representing harm avoidance and self-directedness with medication adherence in Japanese patients with type 2 diabetes. Journal of Pharmaceutical Health Care and Sciences 2018; 4: 16.
  • Fukamachi S, Hashiguchi M, Takahashi K, Mochizuki M. Exploratory evaluation of a commercially available Japanese medical record database as an external control for comparative clinical trials in new drug development: Amyotrophic lateral sclerosis. Neurology and Clinical Neuroscience 2018; 6: 94-99.
  • Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki D, Suzuki H, Nishikimi M, Kawarai-Kefor A, Mato T. The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study. Journal of Intensive Care 2018; 6: 10.
  • Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H. Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa. Scientific Reports 2017; 7: 16383.
  • Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M. Daple coordinates planar polarized microtubule dynamics in ependymal cells and contributes to hydrocephalus. Cell Reports 2017; 20: 960-972.
  • Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy. Intensive Care Medicine 2016; 42: 2106-2107.
  • Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: an exploratory descriptive study using a nationwide claims database. Journal of Epidemiology 2017; 27: 373-380.
  • Takahashi H, Takahashi K, Shimura H, Yasumura S, Suzuki S, Ohtsuru A, Midorikawa S, Ohira T, Ohto H, Yamashita S, Kamiya K. Simulation of expected childhood and adolescent thyroid cancer cases in Japan using a cancer-progression model based on the National Cancer Registry: application to the first-round thyroid examination of the Fukushima Health Management Survey. Medicine 2017; 96(48): e8631.
  • Ishikawa T, Uetake H, Murotani K et al. Genome-wide DNA copy-number analysis in ACTS-CC trial of adjuvant chemotherapy for stage III colonic cancer. Anticancer Res. 2016; 36: 853-860.
  • Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M. Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases. Drug Design, Development and Therapy 2015; 9: 3031-3041.
  • Sugimoto T, Matsumoto T, Hosoi T et al. Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT). Osteoporos Int. 2015; 26: 765-774.
  • Iwase T, Yamamoto K, Ra E et al. Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow. Medicine 2015; 94: e519.
  • Nakashima T, Sato H, Gyo K et al. Idiopathic sudden sensorineural hearing loss in Japan. Acta Oto-Laryngologica 2014; 134: 1158-1163.
  • Atagi S, Katakami N, Yoshioka H et al. Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: a multicenter phase IV study (JO21661). Clin Lung Cancer 2013; 14:407-417.
  • Negoro H, Kanematsu A, Doi M et al. Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. 2012; 3: 809.
  • Ishiguro M, Mochizuki H, Tomita N et al. Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer. BMC Cancer 2012; 12: 281.
  • Shoji S, Suzuki M, Tomono Y et al. Population pharmacokinetics of pregabalin in healthy subjects and patients with post-herpetic neuralgia or diabetic peripheral neuropathy. Br J Clin Pharmacol. 2011; 72: 63-76.
  • Sugano K, Matsumoto Y, Itabashi T et al. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. J Gastroenterol. 2011; 46: 724-735.
  • Yamaguchi K, Mandai M, Oura T et al. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene 2010; 29: 1741-1752.
  • Yoshimura K, Kamoto T, Ogawa O et al. Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study. Int J Urol. 2010; 17: 548-554.
  • Yamashita S, Hbujo H, Arai H et al. Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb. 2008; 15: 292-303.
  • Ito M, Nishiyama H, Kawanishi H et al. P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. J Urol. 2007; 178: 1073-1079.
  • Watanabe D, Suzuma K, Matsui S et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med. 2005; 353: 782-792.
  • Sakai R, Matsui S, Fukushima M et al. Prognostic factor analysis for plaque psoriasis. Dermatology 2005; 211: 103-106.
  • Kanatsu-Shinohara M, Toyokuni S, Morimoto T et al. Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation. Biol Reprod. 2003; 68: 1801-1807.