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教室の主な研究実績

2019年

  • Nonaka T, Igeta M, Matsui S (2019). Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials. Pharmaceutical Statistics. (In press)
  • Sakai Y, Honda M, Matsui S, Komori O, Murayama T, Fujiwara T, Mizuno M, Imai Y, Yoshimura K, Nasti A, Wada T, Iida N, Kitahara M, Horii R, Tamai T, Nishikawa M, Okafuji H, Mizukoshi E, Yamashita T, Yamashita T, Arai K, Kitamura K, Kawaguchi K, Takatori H, Shimakami T, Terashima T, Hayashi T, Nio K, Kaneko S; Hokuriku Liver Study Group (2019). Development of novel diagnostic system for pancreas cancer including early stages measuring mRNA of whole blood cells. Cancer Science. (In press)
  • Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M (2019). [Na+] increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a. Neuron 101, 60-75.
  • Emura T, Matsui S, Chen HY (2019). compound.Cox: univariate feature selection and compound covariate for predicting survival. Computer Methods and Programs in Biomedicine 168, 21-37.
  • Otani T, Noma H, Sugasawa S, Kuchiba A, Goto A, Yamaji T, Kochi Y, Iwasaki M, Matsui S, Tsunoda T (2019). Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models. European Journal of Human Genetics 27, 140-149.
  • Okada E, Takahashi K, Nakamura K, Ukawa S, Takabayashi S, Nakamura M, Sasaki S, Tamakoshi A, Takimoto H (2019). Dietary patterns and impaired abnormal glucose tolerance among Japanese: findings from the National Health and Nutrition Survey, 2012. Public Health Nutrition. (In press)
  • Anzai T, Takahashi K, Watanabe M (2019). Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database. Psychiatry and Clinical Neurosciences 73, 27-33.
  • Emura T, Matsui S, Rondeau V (2019). Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models, Springer. (In press)
  • Matsui S, Igeta M, Toyoizumi K (2019). Biomarker-based phase II and III clinical trials in oncology. In Textbook of Clinical Trials in Oncology. (eds. S. Halabi and S. Michiels), CRC Press. (In press)
  • Takahashi K, Takahashi H, Nakaya T, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K (2019). Factors influencing the proportion of non-examinees in the Fukushima Health Management Survey for childhood and adolescent thyroid cancer: Results from the baseline survey. Journal of Epidemiology. (in press)
  • Kawabata T, Emoto R, Nishino J, Takahashi K, Matsui S (2019). Two-stage analysis for selecting fixed numbers of features in omics association studies. Statistics in Medicine 38(16), 2956-2971.
  • Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T (2019). External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation. (in press)
  • Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki D, Suzuki H, Nishikimi M, Lefor AK, Mato T (2019). A progressive early mobilization program is significantly associated with clinical and economic improvement: A single-center quality comparison study. Critical Care Medicine. (in press)
  • Kasugai D, Hirakawa A, Ozaki M, Nishida K, Ikeda T, Takahashi K, Matsui S, Uenishi N (2019). Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: a retrospective study. Journal of Intensive Care Medicine. (in press)
  • Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H (2019). Steeper macular curvature in eyes with non-highly myopic retinitis pigmentosa. Investigative Ophthalmology & Visual Science. (in press)
  • Kasugai D, Nishikimi M, Nishida K, Higashi M, Yamamoto T, Numaguchi A, Takahashi K, Matsui S, Matsuda N (2019). Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study. Journal of Intensive Care 7, 20.
  • Yamauchi T, Sasaki T, Takahashi K, Umezaki S, Takahashi M, Yoshikawa T, Suka M, Yanagisawa H (2019). Long working hours, sleep-related problems, and near-misses/injuries in industrial settings using a nationally representative sample of workers in Japan. PLoS ONE 14(7), e0219657.

2018年

  • Nishino J, Ochi H, Kochi Y, Tsunoda T, Matsui S (2018). Sample size for successful genome-wide association study of major depressive disorder. Frontiers in Genetics 9: 227.
  • Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich K, Tsunoda T, Matsui S (2018). Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures. Frontiers in Genetics 9: 115.
  • Igeta M, Takahashi K, Matsui S (2018). Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Biometrics 74, 1459-1467.
  • Otani T, Noma H, Nishino J, Matsui S (2018). Re-assessment of multiple testing strategies for more efficient genome-wide association studies. European Journal of Human Genetics 26, 1038-1048.
  • Shimamura F, Hamada C, Matsui S, Hirakawa A (2018). Two-stage approach based on zone and dose findings for two-agent combination phase I/II trials. Journal of Biopharmaceutical Statistics 8, 1-13.
  • Emura T, Nakatochi M, Matsui S, Michimae H, Rondeau V (2018). Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors: Meta-analysis with a joint model. Statistical Methods in Medical Research 27, 2842-2858.
  • Matsui S, Crowley J (2018). Biomarker-stratified phase III clinical trials: enhancement with a subgroup-focused sequential design. Clinical Cancer Research 24, 994-1001.
  • Matsui S, Noma H, Qu P, Yoshio Sakai, Matsui K, Heuck C, Crowley J (2018). Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: application to a randomized clinical trial in multiple myeloma. Biometrics 74, 313-320.
  • Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S (2018). Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice. Free Radical Research 52, 1030-1039.
  • Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N (2018). The authors reply. Critical Care Medicine 46, e1225-e1226.
  • Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N (2018). The authors reply. Critical Care Medicine 46, e1010-e1011.
  • Ogura T, Nakamura Y, Takahashi K, Nishida K, Kobashi D, Matsui S (2018). Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan. Journal of Intensive Care 6, 57.
  • Nishikimi M, Ogura T, Matsui K, Takahashi K, Fukaya K, Liu K, Morita H, Nakamura M, Matsui S, Matsuda N (2018). Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. Journal of Intensive Care 6, 26.
  • Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y (2018). Immune condition of colorectal cancer patients featured by serum chemokines and gene expressions of CD4+ cells in blood. Canadian Journal of Gastroenterology and Hepatology 7436205.
  • Hayashi K, Oshima H, Shimizu M, Kobayashi K, Matsui S, Nishida Y, Usui A (2018). Preoperative six-minute walk distance is associated with postoperative cognitive dysfunction. Annals of Thoracic Surgery 106, 505-512.
  • Nishikimi M, Ogura T, Nishida K, Takahashi K, Fukaya K, Liu K, Nakamura M, Matsui S, Matsuda N (2018). Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. Resuscitation 128, 11-15.
  • Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N (2018). Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial. Critical Care Medicine 46, 1099-1105.
  • Kawai A, Goto T, Shibata T, Tani K, Mizutani S, Nishikawa A, Shibata T, Matsumoto S, Nagata K, Narukawa M, Matsui S, Ando M, Toguchida J, Monden M, Heike T, Kimura S, Ueda R (2018). The current state of therapeutic development for rare cancers in Japan, and proposals for improvement. Cancer Science 109, 1731-1737.
  • Horisaki K, Takahashi K, Ito H, Matsui S (2018). A dose-response meta-analysis to coffee consumption and colorectal cancer risk in the Japanese population: Application of a cubic-spline model. Journal of Epidemiology 28, 503-509.
  • Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Ichikawa M, Ogasawara T, Shindoh J, Nomura F, Yagi T, Yamamoto M, Taniguchi H, Suzuki R, Saka H, Matsui S, Hasegawa Y (2018). Implication of β-lactam plus macrolide combination therapy on mortality in patients with community-onset pneumonia at low risk for drug-resistant pathogens. Respirology 23, 526-534.
  • Nakaya T, Takahashi K, Takahashi H, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K (2018). Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture. Scientific Reports 8:17661.
  • Takahashi K, Shimadzu H (2018). Multiple-cluster detection test for purely temporal disease clustering: Integration of scan statistics and generalized linear models. PLoS ONE 13, e0207821.
  • Okada E, Takahashi K, Takimoto H, Takabayashi S, Kishi T, Kobayashi T, Nakamura K, Ukawa S, Nakamura M, Sasaki S, Tamakoshi A (2018). Dietary patterns among Japanese adults: findings from the National Health and Nutrition Survey, 2012. Asia Pacific Journal of Clinical Nutrition 27, 1120-1130.
  • Tominaga Y, Aomori T, Hayakawa T, Morisky DE, Takahashi K, Mochizuki M (2018). Relationship between medication adherence and glycemic control in Japanese patients with type 2 diabetes. Pharmazie 73, 609-612.
  • Kuriki S, Takahashi K, Hara H (2018). Multiplicity adjustment for temporal and spatial scan statistics using Markov property. Japanese Journal of Statistics and Data Science 1, 191-213.
  • Matsuhisa T, Takahashi N, Aomatsu M, Takahashi K, Nishino J, Ban N, Mercer SW (2018). How many patients are required to provide a high level of reliability in the Japanese version of the CARE Measure? A secondary analysis. BMC Family Practice 19, 138.
  • Tominaga Y, Aomori T, Hayakawa T, Kijima N, Morisky DE, Takahashi K, Mochizuki M (2018). Possible associations of personality traits representing harm avoidance and self-directedness with medication adherence in Japanese patients with type 2 diabetes. Journal of Pharmaceutical Health Care and Sciences 4, 16.
  • Fukamachi S, Hashiguchi M, Takahashi K, Mochizuki M (2018). Exploratory evaluation of a commercially available Japanese medical record database as an external control for comparative clinical trials in new drug development: Amyotrophic lateral sclerosis. Neurology and Clinical Neuroscience 6, 94-99.
  • Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki D, Suzuki H, Nishikimi M, Kawarai Kefor A, Mato T (2018). The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study. Journal of Intensive Care 6, 10.
  • Hirakawa A, Sato H, Daimon T, Matsui S (2018). Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents. Springer.
  • 山内貴史, 梅崎重夫, 平岡伸隆, 高橋邦彦, 須賀万智, 柳澤裕之 (2018). 過重労働過労と業務上の事故. 産業医学ジャーナル 41, 24-127.
  • 高橋邦彦(翻訳,編集委員)(2018). 生物統計学, 他. 日本統計学会(翻訳)統計科学百科事典. 丸善出版.
  • 松井茂之 (2018). オミクス研究における検証的解析と探索的解析:多重検定とP値を中心に.計量生物学 38, 127-139.
  • 丹後俊郎, 松井茂之(編)(2018).新版医学統計学ハンドブック.朝倉書店.
  • 大谷隆浩, 菅澤翔之助, 野間久史 (2018). 希少な遺伝的変異を対象とする集約型関連解析. 計算機統計学 31(1), 17-33.

2017年

  • Sugasawa S, Noma H, Otani T, Nishino J, Matsui S (2017). An efficient and flexible test for rare variant effects. European Journal of Human Genetics 25, 752-757
  • Toyoizumi K, Matsui S (2017). Correcting estimation bias in randomized clinical trials with a test of treatment-by-biomarker interaction. Statistics in Biopharmaceutical Research 9, 172-179
  • Noma H, Tanaka S, Matsui S, Cipriani A, Furukawa TA (2017). Quantifying indirect evidence in network meta-analysis. Statistics in Medicine 36, 917-927
  • Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H (2017). Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa. Scientific Reports 7, 16383
  • Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M (2017). Daple coordinates planar polarized microtubule dynamics in ependymal cells and contributes to hydrocephalus. Cell Reports 20, 960-972
  • Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S (2017). A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score. Scandinavian Journal of Trauma, Resuscitation, and Emergency Medicine 25, 49
  • Takahashi H, Takahashi K, Shimura H, Yasumura S, Suzuki S, Ohtsuru A, Midorikawa S, Ohira T, Ohto H, Yamashita S, Kamiya K (2017). Simulation of expected childhood and adolescent thyroid cancer cases in Japan using a cancer-progression model based on the National Cancer Registry: Application to the first-round thyroid examination of the Fukushima Health Management Survey. Medicine 96, e8631
  • Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H (2017). Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: an exploratory descriptive study using a nationwide claims database. Journal of Epidemiology 27, 373-380
  • Takahashi K, Tachimori H, Kan C, Nishi D, Okumura Y, Kato N, Takeshima T (2017). Spatial analysis for regional behavior of patients with mental disorders in Japan. Psychiatry and Clinical Neurosciences 71, 254-261
  • Sumi T, Oguri M, Fujimaki T, Horibe H, Kato K, Matsui K, Takeuchi I, Murohara T, Yamada Y (2017). Association of renal function with clinical parameters and conditions in a longitudinal population-based epidemiological study. Biomedical Reports 6, 242-250
  • Matsui S (2017). Phase III clinical trial designs incorporating predictive biomarkers: an overview. In Frontiers of Biostatistical Methods and Applications in Clinical Oncology. (eds. S. Matsui, J. Crowley), Springer
  • Matsui S, Crowley J (editors). Frontiers of Biostatistical Methods and Applications in Clinical Oncology, Springer, 2017.

2016年

  • Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S (2016). CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy. Intensive Care Medicine 42, 2106-2107
  • Ishikawa T, Uetake H, Murotani K, Kobunai T, Ishiguro M, Matsui S, Sugihara K (2016). Genome-wide DNA copy-number analysis in ACTS-CC trial of adjuvant chemotherapy for stage III colonic cancer. Anticancer Research 36, 853-860
  • Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H (2016). Association between photoreceptor regeneration and visual acuity following surgery for rhegmatogenous retinal detachment. Investigative Ophthalmology & Visual Science 57, 889-898
  • Sadashima E, Hattori S, Takahashi K (2016). Meta-analysis of prognostic studies for a biomarker with a study-specific cut-off value. Research Synthesis Methods 7, 402-419
  • 竹島正, 立森久照, 高橋邦彦 (2016). 認知症施策とこれからの精神保健医療福祉のあり方. 連載:わが国の認知症施策の未来6. 老年精神医学雑誌 27, 777-782
  • 竹島正, 立森久照, 高橋邦彦, 山之内芳雄 (2016). 精神保健医療福祉の改革ビジョンの成果と今後の課題. 公衆衛生 80, 790-796
  • 高橋邦彦 (2016). 空間疫学への誘い-難病の地図から何が見えるか. 岩波データサイエンス刊行委員会(編). 岩波データサイエンス Vol.4. 岩波書店
  • 加藤直広, 立森久照, 高橋邦彦 (2016). 地図の上で階層ベイズモデリング. 岩波データサイエンス刊行委員会(編). 岩波データサイエンス Vol.4. 岩波書店.

2015年

  • Hirakawa A, Wages NA, Sato H, Matsui S (2015). A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Statistics in Medicine 34, 3194-3213
  • Hirakawa A, Matsui S (2015). Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials. Japanese Journal of Biometrics 36, 1-12
  • Choai Y, Matsui S (2015). Estimation of treatment effects in all-comers randomized clinical trials with a predictive marker. Biometrics 71, 25-32
  • Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H (2015). Sex-related differences in ocular blood flow of healthy subjects using laser speckle flowgraphy. Investigative Ophthalmology & Visual Science 56, 4880-4890
  • Sugimoto T, Matsumoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Fukunaga M, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Okubo N, Shiraki M, Nakamura T (2015). Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT). Osteoporosis International 26, 765-774
  • Takanari K, Araki Y, Okamoto S, Sato H, Yagi S, Toriyama K, Yokotyama K, Murotani K, Matsui S, Wakabayashi T, Kamei Y (2015). Operative wound related complications after cranial revascularization surgeries. Journal of Neurosurgery 123, 1145-1150
  • Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H (2015). Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow. Medicine 94, e519
  • Takahashi K, Shimadzu H (2015). The daily incidence of out-of-hospital cardiac arrest unexpectedly increases around New Year’s Day in Japan. Resuscitation 96, 156-162
  • Nomura K, Takahashi K, Hinomura Y, Kawaguchi G, Matsushita Y, Marui H, Anzai T, Hashiguchi M, Mochizuki M (2015). Effect of database profile variation on drug safety assessment: An analysis of spontaneous adverse events reports of Japanese cases. Drug Design, Development and Therapy 9, 3031-3041
  • Simon R, Matsui S, Buyse M (2015). Clinical trials for predictive medicine: new paradigms and challenges. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Daimon T, Hirakawa A, Matsui S (2015). Phase I dose-finding designs and their applicability to targeted therapies. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Matsui S, Choai Y, Nonaka T (2015). Phase III all-comers clinical trials with a predictive biomarker. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Matsui S (2015). Statistical issues in clinical development and validation of genomic signatures. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Noma H, Matsui S (2015). Univariate analysis for gene screening: beyond the multiple testing. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Matsui S (2015). Development and validation of continuous genomic signatures in randomized clinical trials. In Design and Analysis of Clinical Trials for Predictive Medicine. (eds. S. Matsui, M. Buyse, R. Simon), CRC Press
  • Matsui S, Buyse M, Simon R (editors). Design and Analysis of Clinical Trials for Predictive Medicine. CRC Press, 2015.